Faculty
Margaret IP
Paul KS CHAN
Mamie HUI
Zigui CHEN
Christopher KC LAI
Rita WY NG
Siaw Shi BOON
Xiao YANG
Yun Kit YEOH
Chiu Yeung CHAN
Research, Administrative and Honorary Staff
Elite Alumni Microbiologists
Hospital Staff
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Faculty > Paul Kay Sheung CHAN 陈基湘
Personal information
Name Paul Kay Sheung CHAN 陈基湘
Academic / Professional Qualifications MBBS (HK), MSc (Virology) (Lond), MD (CUHK), FRCPath, FHKCPath, FHKAM (Pathology)
Academic title & affiliations Professor (Clinical), Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong
Email paulkschan@cuhk.edu.hk
Current Appointments
(Including honorary appointments)
  • Deputy Director, Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, Chinese University of Hong Kong
  • Honorary Consultant in Microbiology, New Territories East Cluster, Hong Kong Hospital Authority
  • Visiting Professor of College of Life Science and Bioengineering, Beijing University of Technology
  • Member of the Global Outbreak Alert and Response Network of World Health Organization
  • Examiner of the Hong Kong College of Pathologists

Service to Hong Kong SAR Government:

  • Member of Rabies Appeals Board, since 2014
  • Member of Licensing Appeals Board, since 2014
  • Member of National Verification Committee for Measles Elimination in Hong Kong, since 2012.
  • Member of Solicitors Disciplinary Tribunal Panel under the Court of Final Appeal, since 2011.
  • Member of Advisory Council on Food and Environmental Hygiene, Hong Kong SAR Government, since 2009.
  • Scientific Advisor of Hong Kong Observatory, Hong Kong SAR Government, since 2008.
  • Member of Working Group on Rotavirus Vaccination, since 2008.
  • Member of Working Group on Human Papillomavirus Vaccination, since 2006.
  • Member of Scientific Committee on Emerging and Zoonotic Diseases of the Centre for Health Protection, since 2004.
  • Member of Grant Review Board for the Health and Medical Research Fund, (previously the Research Fund for the Control of Infectious Diseases), since 2004.
 
Research
ORCID
ORCID iD iconorcid.org/0000-0002-6360-4608
ResearcherID
Research interest
Human papillomavirus (HPV):
1.
Epidemiology of cervical HPV infection including the prevalence and risk factors for infection among different populations.
2.
Distribution of HPV genotypes and their attribution to the development of cervical precancers and cancers, and also the trend of change over time.
3.
Determinants for progression of HPV-infected lesions to cervical neoplasia, including coinfection with other viruses, host genetic factors, host immune status and viral sequence variations.
4.
Epidemiological risk association between HLA types and infection with different HPV genotypes on the development of cervical neoplasia.
5.
Phylogenetics and lineage classification system for HPV types (HPV52 and HPV58), which are found in higher frequency in East Asia, but rare in cancers worldwide.
6.
T-cell epitope mapping for HPV52 and HPV58.
7.
Oncogenic risk of different variants of HPV16, HPV52 and HPV58.
8.
Viral genome physical and methylation status of HPV and the potential application in cervical cancer screening and triage.
   
Influenza:
1.
Epidemiology including disease burden, seasonality and their correlation with meteorological variations.
2.
Pathogenesis including clinical and in-vitro studies on seasonal and avian influenza viruses.
3.
Response, attitude and acceptance to seasonal and pandemic influenza vaccines.
4.
Development and evaluation of molecular methods for rapid diagnosis and strain characterization.
5.
Clinical response and effectiveness of antiviral treatment.
   
General clinical virology:
1.
Epidemiology, seasonality and disease burden of respiratory and diarrhoeal viruses.
2.
Molecular epidemiology of common viral infections, including hepatitis C and hepatitis E.
3.
Opportunistic viral infections in paediatric transplant recipients, including cytomegalovirus, human herpes virus types 6 and 7, and polyomaviruses.
 
Postgraduate students
Information for Postgraduate Study in Department of Microbiology
 
Name of student PhD student: Miss Echo Chu Qing ZHANG
Projects / Research areas Environmental pollutants and human papillomavirus-mediated carcinogenesis
 
Name of student MPhil student: Miss Grace Pui Yiu CHEUNG
Projects / Research areas Oncogenic risk of human papillomavirus E7 variants
 
Name of student MPhil student: Miss Emily Tsui
Projects / Research areas Oncogenic risk of HPV 52 intratypic variants
 
Name of student MPhil student: Mr Leon Tsz On LAI
Projects / Research areas Human papillomavirus (tentative)
 
Name of student MPhil student: Mr Dennis Cheng Hua HU
Projects / Research areas Human papillomavirus (tentative)
 
Awards
Name of award Outstanding Staff and Teams Award presented by the Hong Kong Hospital Authority
(For being a leader of the Virology Rapid Testing Centre during the avian influenza A H5N1 outbreak in Hong Kong in 1997.)
Date 1999
Place Hong Kong
 
Name of award International Virological Award - Medal "100 Years of Virology"
(For the contribution in the development of virology and international collaboration of virology.)
Date 2008
Place presented by the All-Russian Academy of Medical Sciences and Scientific Council of the D. I. Ivanovsky Institute of Virology
 
Publications (Representative)
Publications on human papillomavirus:
  1. Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PKS*. Geographical distribution and risk association of human papillomavirus genotype 52–variant lineages. Journal of Infectious Diseases. 2014 May 30. doi: 10.1093/infdis/jiu310
  2. Chan PKS*, Zhang C, Park JS, Smith-McCune KK, Palefsky JM, Giovannelli L, Coutlée F, Hibbitts S, Konno R, Settheetham-Ishida W, Chu TY, Ferrera A, Alejandra Picconi M, De Marco F, Woo YL, Raiol T, Piña-Sánchez P, Bae JH, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Fiander AN, Capra G, Young Ki E, Tan Y, Chen Z, Burk RD, Chan MC, Cheung TH, Pim D, Banks L. Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations. International Journal of Cancer. 2013 Jun 1;132(11):2528-2536.
  3. Cheung JL Cheung TH, Yu MY, Chan PKS*. Virological characteristics of cervical cancers carrying pure episomal form of HPV16 genome. Gynecologic Oncology 2013; 131: 374-379. Chan PKS*, Picconi MA, Cheung TH, Giovannelli L, Park JS. Laboratory and clinical aspects of human papillomavirus testing. Critical Reviews in Clinical Laboratory Sciences 2012; 49: 117-136.
  4. Chan PKS*. Human papillomavirus type 58: the unique role in cervical cancers in East Asia. Cell and Bioscience 2012; 2:17.
  5. Sham CL, To KF, Chan PKS, Lee DLY, Tong MCF, van Hasselt A*. Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papillomas, nasal polyp, and hypertrophied turbinate in Hong Kong patients. Head and Neck 2012; 34: 520-533.
  6. Lee A*, Chan PKS, Lau LCH, Chan TTN. How would family physicians facilitate the uptake of HPV vaccination: focus group study on parents and single women in Hong Kong. The Hong Kong Practitioner 2011; 33: 107-114.
  7. Chan PKS*, Cheung TH, Li WH, Yu MY, Chan MY, Yim SF, Ho WC, Yeung AC, Ho KM, Ng HK. Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China. International Journal Cancer. 2012; 131: 692-705.
  8. Leung WY*, Chan PKS, Lau KH, Ho KM. The prevalence of human papilloma virus in the anal region of male Chinese attendees in three public sexually transmitted disease clinics in Hong Kong. Hong Kong Journal of Dermatology and Venereology 2011; 19: 6-13.
  9. Chan PKS*, Luk AC, Park JS, Smith-McCune KK, Palefsky JM, Konno Y, Giovannelli L, Coutlée F, Hibbitts S, Chu TY, Settheetham-Ishida W, Picconi MA, Ferrera A, De Marco F, Woo YL, Raiol T, Piña-Sánchez P, Cheung JLK, Bae JH, Chirenje MZ, Magure T, Moscicki AB, Fiander AN, Di Stefano R, Cheung TH, Yu MM, Tsui SK, Pim D, Banks L. Identification of human papillomavirus type 58 lineages and the distribution worldwide. Journal of Infectious Diseases 2011; 203: 1565-1573.
  10. Chan PKS*, Liu SJ, Cheung JLK, Cheung TH, Yeo W, Chong P, Man S. T-cell response to human papillomavirus type 52 L1, E6, and E7 peptides in women with transient infection, cervical intraepithelial neoplasia, and invasive cancer. Journal of Medical Virology 2011; 83:1023-1030.
  11. Yip YC, Ngai KLK, Vong HT, Tzang LCH, Ji S, Yang M, Chan PKS*. Prevalence and genotype distribution of cervical human papillomavirus infection in Macao. Journal of Medical Virology 2010; 82: 1724-1729.
  12. Hlaing T, Yip YC, Ngai KL, Vong HT, Wong SI, Ho WC, Batalha SL, Chan PKS*. Distribution of human papillomavirus genotypes among cervical intraepithelial neoplasia and invasive cancers in Macao. Journal of Medical Virology 2010; 82: 1600-1605.
  13. Chan PKS*, Liu SJ, Cheung TH, Yeo W, Ngai SM, Cheung JLK, Chong P, Man S. T-cell response to human papillomavirus type 58 L1, E6, And E7 peptides in women with cleared infection, cervical intraepithelial neoplasia, or invasive cancer. Clinical and Vaccine Immunology 2010; 17: 1315-1321.
  14. Chan PKS*, Chang AR, Yu MY, Li WH, Chan MYM, Yeung ACM, Cheung TH, Yau TN, Wong SM, Yau CW, Ng HK. Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies. International Journal of Cancer 2010; 126: 297-301.
  15. Tam LS*, Chan PKS, Ho SC, Yu MMY, Yim SF, Cheung TH, Wong MCS, Li EK. Natural history of cervical papilloma virus infection in systemic lupus erythematosus – a prospective cohort study. Journal of Rheumatology 2010; 37: 330-40.
  16. Chan PKS*, Ho WCS, Yu MY, Pong WM, Chan ACL, Chan AKC, TH Cheung, MCS Wong, KF To, HK Ng. Distribution of human papillomavirus types in cervical cancers in Hong Kong: current situation and changes over the last decades. International Journal of Cancer 2009; 125: 1671–1677.
  17. Chan PKS*, Ho WCS, Wong MCS, Chang AR, Chor JSY, Yu MY. Epidemiologic risk profile of infection with different groups of human papillomaviruses. Journal of Medical Virology 2009; 81: 1635–1644.
  18. Chan PKS*, Luk ACS, Luk TNM, Lee KF, Cheung JLK, Ho KM, Lo KK. Distribution of human papillomavirus types in anogenital warts of men. Journal of Clinical Virology 2009; 44: 111-114.
  19. Cheung JLK, Cheung TH, Ng CWY, Yu MY, Wong MCS, Siu SSN, Yim SF, Chan PKS*. Analysis of HPV18 Viral Load and Integration Status from Low-Grade Cervical Lesion to Invasive Cervical Cancer. Journal of Clinical Microbiology, 2009: 47: 287-293.
  20. Bae JH, Cheung JLK, Lee SJ, Luk ACS, Tong SY, Chan PKS, Park JS*. Distribution of Human Papillomavirus Type 58 Variants in Progression of Cervical Dysplasia in Korean Women. J Microbiol Biotechnol 2009; 19: 1051–1054.
  21. Wong WCW*, Fong B, Chan PKS. Acceptance of human papillomavirus vaccination among first year female university students in Hong Kong. Sexual Health 2009; 6: 264-271.
  22. Cheung JLK, Cheung TH, Tang JWT, Chan PKS*. Increase of integration events and infection loads of human papillomavirus type 52 with lesion severity from low-grade cervical lesion to invasive cancer. Journal of Clinical Microbiology 2008; 46: 1356-1362.
  23. Liu HC, Chen GG*, Vlantis AC, Tong MCF, Chan PKS, van Hasselt CA. Induction of cell cycle arrest and apoptosis by 5-fluorouracil in laryngeal cancer cells containing HPV16 E6 and E7 oncoproteins. Clinical Biochemistry 2008; 41: 1117-1125.
  24. Chan PKS*. Commonly asked questions on human papillomavirus vaccine. Hong Kong Journal of Dermatology and Venereology 2008; 16: 12-17.
  25. Chan PKS*, Cheung JLK, Cheung TH, Lo KWK, Yim SF, Siu SSN, Tang JW. Profile of viral load, integration and E2 gene disruption of HPV58 in normal cervix and cervical neoplasia. Journal of Infectious Diseases 2007; 196: 868-875.
  26. Chan PKS*, Cheung JLK, Cheung TH, Lin CK, Siu SSN, Yu MMY, Tang JW, Lo KWK, Yim SF, Wong YF, To KF, Ng HK, Chung TKH. HLA-DQB1 polymorphisms and risk for cervical cancer: a case-control study in a southern Chinese population. Gynecologic Oncology 2007; 105: 736-741.
  27. Chan PKS*, Cheung TH, Lin CK, Siu SSN, Yim SF, Lo KWK, Cheung JLK, Tam AOY, Tang JW. Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese women. Journal of Medical Virology 2007; 79: 970-976.
  28. Cheung JL, Lo KW, Cheung TH, Tang JW, Chan PKS*. Viral load, E2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia. Journal of Infectious Diseases 2006; 194: 1706-1712.
  29. Chan PKS*, Cheung JLK, Cheung TH, Lin CK, Tam AOY, Chan DPC, Zhou DX, Lo KWK, Yim SF, Siu SSN. HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women. International Journal of Cancer 2006; 118: 1430-1435.
  30. Chan PKS*, Cheung THH, Tam AOH, Lo KWH, Yim SFH, Yu MMH, To KFH, Wong YFH, Cheung JLK, Chan DPC, Hui MH, Ip M. Biases in human papillomavirus genotype prevalence assessment associated with commonly used consensus primers. International Journal of Cancer 2006; 118: 243-245.
  31. Chan PKS*, Yu MMY, Cheung TH, To KF, Lo KWK, Cheung JLK, Tong JHM. Detection and quantitation of human papillomavirus DNA in primary tumour and lymph nodes of patients with early stage cervical carcinoma. Journal of Clinical Virology 2005; 33: 201-205.
  32. Chan PKS*. Epidemiology of human papillomavirus in Asia: Do HPV-52 and HPV-58 play a special role? Papillomavirus Report 2005; 16: 265-271.
  33. Chan DPC, Cheung TH, Tam AOY, Cheung JLK, Yim SF, Lo KWK, Siu NSS, Zhou DX, Chan PKS*. Risk association of HLA-A allele and high-risk HPV infection for cervical neoplasia in Chinese women. Journal of Infectious Diseases 2005; 192: 1749-1756.
  34. Tam LS*, Chan AYK, Chan PKS, Chang AR, Li EK. Higher prevalence of squamous intraepithelial lesion in Systemic Lupus Erythematosus - association with human papillomavirus infection. Arthritis and Rheumatism 2004; 11: 3619-3625.
  35. Du J, Chen GG*, Vlantis AC, Chan PKS, Tsang RKY, van Hasselt CA. Resistance to apoptosis of HPV 16-infected laryngeal cancer cells is associated with decreased Bak and increased Bcl-2 expression. Cancer Letters 2004; 205: 81-88.
  36. Yu MY, Tong JHM, Chan PKS, Lee TL, Chan MWY, Chan AWH, Lo KW, To KF. Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3P21 in cervical cancers. International Journal of Cancer 2003; 105: 204-209.
  37. Chan PKS*, Lam CW, Cheung TH, Li WWH, Lo KWK, Chan MYM, Cheung JLK, Cheng AF. Association of human papillomavirus type 58 variant with the risk of cervical cancer. Journal of the National Cancer Institute 2002; 94: 1249-1253.
  38. Chan PKS*, Lam CW, Cheung TH, Li WWH, Lo KW, Chan MY, Cheung JL, Xu LY, Cheng AF. Human papillomavirus 16 intratypic variant infection and risk for cervical neoplasia in Southern China. Journal of Infectious Diseases 2002; 186: 696-700.
  39. Chan PKS*, Mak KH, Cheung JLK, Tang NLS, Chan DPC, Lo KK, Cheng AF. Genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinic patients in Hong Kong. Journal of Medical Virology 2002; 68: 273-277.
  40. Chan PKS*, Chang AR, Tam WH, Cheung JLK, Cheng AF. Prevalence and genotype distribution of cervical human papillomavirus infection: comparison between pregnant women and non-pregnant controls. Journal of Medical Virology 2002; 67: 583-588.
  41. Chan PKS*, Chang AR, Cheung JLK, Chan DPC, Xu LY, Tang NLS, Cheng AF. Determinants of cervical human papillomavirus infection: differences between high and low oncogenic risk types. Journal of Infectious Diseases 2002; 185: 28-35.
  42. Chan PKS*, Chan MYM, Li WWH, Chan DPC, Cheung JLK, Cheng AF. Association of human betaherpesviruses with the development of cervical cancer: bystanders or cofactors. Journal of Clinical Pathology 2001; 54: 48-53.
  43. Chan PKS*, Li WH, Chan MYM, Cheng AFB. Detection of human herpesvirus 8 in cervical cells of Chinese women with abnormal Papanicolaou smears. Clinical Infectious Diseases 1999; 29: 1584-1585.
  44. Chan PKS*, Li WH, Chan MYM, Ma WL, Cheung JLK, Cheng AF. High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions. Journal of Medical Virology 1999; 59: 232-238.
 
Publications on influenza:
  1. Chan MC, Lee N, Ngai KL, Leung TF, Chan PKS*. Clinical and virologic factors associated with reduced sensitivity of rapid influenza diagnostic tests in hospitalized elderly patients and young children. Journal of Clinical Microbiology 2014; 52: 497-501.
  2. Chan MC, Lee N, Lui GC, Ngai KK, Wong RY, Choi KW, Chan PKS. Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009. Influenza Other Respiratory Viruses. 2013; 7: 235-239.
  3. Wong SY, Wong CK, Chan FW, Chan PKS, Ngai K, Mercer S, Woo J. Chronic psychosocial stress: does it modulate immunity to the influenza vaccine in Hong Kong Chinese elderly caregivers? Age (Dordr). 2013; 35: 1479-1493.
  4. Chan MC, Lee N, Chan PKS, To KF, Wong RY, Law CO, Ngai KL, Sung JJ. Intestinal binding of seasonal influenza A viruses to DC-SIGN(+) CD68(+) cells. Influenza Other Respiratory Viruses. 2013; 7: 228-230.
  5. Chan PKS, Lee N, Zaman M, Adisasmito W, Coker R, Hanshaoworakul W, Gasimov V, Oner AF, Dogan N, Tsang O, Phommasack B, Touch S, Bamgboye E, Swenson A, Toovey S, Dreyer NA. Determinants of antiviral effectiveness in influenza virus A subtype H5N1. Journal of Infectious Diseases. 2012; 206: 1359-1366.
  6. Chan PKS*, Chan MC, Cheung JL, Lee N, Leung TF, Yeung AC, Wong MC, Ngai KL, Nelson EA, Hui DS. Influenza B lineage circulation and hospitalisation rate in a subtropical city, Hong Kong, 2000-2010. Clinical Infectious Diseases. 2013; 56: 677-684.
  7. Chan MC, Lee N, Ngai KL, Wong BC, Lee MK, Choi KW, Lai RW, Chan PKS*. A "pre-seasonal" hospital outbreak of influenza pneumonia caused by the drift variant A/Victoria/361/2011-like H3N2 viruses, Hong Kong, 2011. Journal of Clinical Virology. 2013; 56: 219-225.
  8. Oner AF, Dogan N, Gasimov V, Adisasmito W, Coker R, Chan PKS, Lee N, Tsang O, Hanshaoworakul W, Zaman M, Bamgboye E, Swenson A, Toovey S, Dreyer NA. H5N1 Avian Influenza in Children. Clinical Infectious Diseases 2012; 55: 26–32.
  9. Ng AKL, Lam MKH, Zhang H, Liu J, Au SWN, Chan PKS, Wang J, Shaw PC. Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein. Journal of Virology 2012; 86: 6758-6767.
  10. Chor JSY, Pada SK, Stephenson I, Goggins WB, Tambyah PA, Medina M, Lee N, Leung TF, Ngai KL, Law SK, Rainer TH, Griffiths S, Chan PKS*. Differences in the compliance with hospital infection control practices during the 2009 influenza H1N1 pandemic in three countries. Journal of Hospital Infection 2012; 81: 98-103.
  11. Ng AKL, Chan WH, Choi ST, Lam MKH, Lau KF, Chan PKS, Au SWN, Fodor E, Shaw PC. Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627. PLoS One 2012; 7: e36415.
  12. Lam WY, Yeung ACM, Chan PKS*. Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypes. Virology Journal 2011, 8:554.
  13. Lam WY, Ngai KLK, Chan PKS*. Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses. Virology Journal 2011, 8: 528.
  14. Chan MCW, Lee N, Chan PKS, To KF, Wong RYK, Ho WS, Ngai KLK, Sung JJY. Seasonal influenza A virus in feces of hospitalized adults. Emerging Infectious Diseases 2011; 17: 2038-2042.
  15. Lee N, Chan PKS, Lui GC, Wong BC, Sin WW, Choi KW, Wong RY, Lee EL, Yeung AC, Ngai KL, Chan MC, Lai RW, Yu AW, Hui DS. Complications and outcomes of pandemic 2009 Influenza A (H1N1) virus infection in hospitalized adults: how do they differ from those in seasonal influenza? Journal of Infectious Diseases 2011; 203: 1739-1747.
  16. Lee N, Chan PKS, Wong CK, Wong KT, Choi KW, Joynt GM, Lam P, Chan MC, Wong BC, Lui GC, Sin WW, Wong RY, Lam WY, Yeung AC, Leung TF, So HY, Yu AW, Sung JJ, Hui DS. Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia. Antiviral Therapy 2011; 16: 237-247.
  17. Lee N. Wong CK, Chan PKS, Chan MCW, Wong RYK, Lun SWM, Ngai KLK, Lui GCY, Wong BCK, Lee SKW, Choi KW, Hui DSC. Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults. PLoS ONE 2011; 6(10):e26050.
  18. Chor JSY, Pada SK, Stephenson I, Goggins WB, Tambyah PA, Clarke TW, Medina M, Lee N, Leung TF, Ngai KLK, Law SK, Rainer TH, Griffiths S, Chan PKS*. Seasonal influenza vaccination predicts pandemic H1N1 vaccination uptake among healthcare workers in three countries. Vaccine 2011; 29: 9364-7369.
  19. Chan PKS*, Lee N, Joynt GM, Choi KW, Cheung JL, Yeung AC, Lam P, Wong R, Leung BW, So HY, Lam WY, Hui DC. Clinical and virological course of infection with haemagglutinin D222G mutant strain of 2009 pandemic influenza A (H1N1) virus. Journal of Clinical Virology 2011; 50: 320-324.
  20. Cheng FWT, Chan PKS, Leung WK, Lee V, Shing MK, Yeung ACM, Li CK. Pandemic (H1N1) 2009 vaccine in paediatric oncology patients : one dose or two doses? British Journal of Haematology 2011.
  21. Adisasmito W, Chan PKS, Lee N, Oner AF, Gasimov V, Zaman M, Bamgboye, Dogan N, Starzyk K, Dreyer NA, Toovey S. Strengthening observational evidence for antiviral effectiveness in influenza A (H5N1). Journal of Infectious Diseases 2011; 204: 810-11.
  22. Lee N, Chan PKS*, Lam WY, Szeto CC, Hui DS. Co-infection with pandemic H1N1 and seasonal H3N2 influenza viruses.Annals of Internal Medicine 2010; 152: 618-619.
  23. Ngai KL, Lam WY, Lee N, Leung TF, Hui DS, Chan PKS*. Allele-specific conventional reverse-transcription polymerase chain reaction as a screening assay for discriminating influenza A H1N1 (H275Y) oseltamivir-resistant and wild-type viruses.Journal of Medical Virology 2010; 82: 1295-1298.
  24. Lam WY, Leung TF, Lee N, Cheung JL, Yeung AC, Ho YI, Chan RC, Fung KS, Barr IG, Hui DS, Sung JJ, Chan PKS*. Development and comparison of molecular assays for the rapid detection of the pandemic influenza A (H1N1) 2009 virus.Journal of Medical Virology 2010; 82: 675-683.
  25. Ooi LS, Ho WS, Ngai KL, Tian L, Chan PKS*, Sun SS, Ooi VE. Narcissus tazetta lectin shows strong inhibitory effects against respiratory syncytial virus, influenza A (H1N1, H3N2, H5N1) and B viruses. Journal of Biosciences 2010; 35: 95-103. 
  26. Lee N, Choi KW, Chan PKS*, Hui DS, Lui GC, Wong BC, Wong RY, Sin WY, Hui WM, Ngai KL, Cockram CS, Lai RW, Sung JJ. Outcomes of adults hospitalised with severe influenza. Thorax 2010; 65: 510-515.
  27. Adisasmito W, Chan PKS, Lee N, Oner AF, Gasimov V, Aghayev F, Zaman M, Bamgboye E, Dogan N, Coker R, Starzyk K, Dreyer NA, Toovey S. Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a global patient registry. Journal of Infectious Diseases 2010; 202: 1154-1160.
  28. Wong SY, Wong EL, Chor J, Kung K, Chan PKS, Wong C, Griffiths SM. Willingness to accept H1N1 pandemic influenza vaccine: a cross-sectional study of Hong Kong community nurses. BMC Infectious Diseases. 2010; 29: 316.
  29. Hon KL, Leung TF, Cheung KL, Ng PC, Chan PKS. Influenza and parainfluenza associated pediatric ICU morbidity. Indian Journal of Pediatrics 2010; 1097-1101.
  30. Lau JT, Tsui HY, Kim JH, Chan PKS, Griffiths S. Monitoring of perceptions, anticipated behavioral and psychological responses related to H5N1 influenza. Infection 2010; 38: 275-283.
  31. Chan WH, Ng AK, Robb NC, Lam MK, Chan PKS, Au SW, Wang JH, Fodor E, Shaw PC. Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are critical for oligomerization and ribonucleoproteins activities. Journal of Virology 2010; 84: 7337-7345.
  32. Hui DS, Lee N, Chan PKS. Clinical management of pandemic 2009 influenza A(H1N1) infection. Chest 2010; 137:1-10.
  33. Lee N, Wong CK, Chan PKS, Lindegardh N, White NJ, Hayden FG, Wong EH, Wong KS, Cockram CS, Sung JJ, Hui DS. Acute encephalopathy associated with influenza A infection in adults. Emerging Infectious Diseases 2010; 16: 139-142.
  34. Chan PKS*, Mok HY, Lee TC, Chu IM, Lam WY, Sung JJ. Seasonal influenza activity in Hong Kong and its association with meteorological variations. Journal of Medical Virology2009; 81: 1797-1806.
  35. Chan PKS*. A review on human influenza A H5N1 infections in Hong Kong. Science in China Series C: Life Sciences, 2009; 52: 412-418.
  36. Chor JS, Ngai KL, Goggins WB, Wong MC, Wong SY, Lee N, Leung TF, Rainer TH, Griffiths S, Chan PKS*. Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys. British Medical Journal 2009; 339: b3391.
  37. Lee N, Chan PKS*, Hui DS, Rainer TH, Wong E, Choi KW, Lui GC, Wong BC, Wong R, Lam WY, Chu IM, Lai RW, Cockram CS, Sung JJ. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. Journal of Infectious Diseases 2009; 200: 492-500.
  38. Lam WY, Tang JW, Yeung AC, Chiu LC, Sung JJ, Chan PKS*. Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. Journal of Virology 2008; 82: 2741-2751.
  39. Tang JW, Ngai LL, Chan PKS*. Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans. Journal of Medical Virology 2008; 80: 1992-1996.
  40. Tang JW, Ngai KL, Wong JC, Lam WY, Chan PKS*. Emergence of adamantane-resistant influenza A(H3N2) viruses in Hong Kong between 1997 and 2006. Journal of Medical Virology 2008; 80: 895-901.
  41. Jennings LC, Monto AS, Chan PKS, Szucs TD, Nicholson KG. Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans. Lancet Infectious Diseases 2008; 8: 650-658.
  42. Ng AK, Zhang H, Tan K, Li Z, Liu J, Chan PKS, Li SM, Chan WY, Au SW, Joachimiak A, Walz T, Wang JH, Shaw PC. Structure of influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. Journal of the Federation of American Societies for Experimental Biology 2008; 22: 3638-3647.
  43. Hui DS, Woo J, Hui E, Ip M, To KW, Cheuk ES, Lam WY, Shan A, Chan PKS. Influenza-like illness in residential care homes: a study of the incidence, aetiological agents, natural history and health resource utilization. Thorax 2008; 63: 690-697.
  44. Tang JW, Ngai KL, Lam WY, Chan PKS. Seasonality of influenza A(H3N2) virus: a Hong Kong perspective (1997-2006).PLoS ONE 2008; 3: e2768.
  45. Lee N, Chan PKS, Choi KW, Lui G, Wong B, Cockram CS, Hui DS, Lai R, Tang JW, Sung JJ. Factors associated with early hospital discharge of adult influenza patients. Antiviral Therapy 2007; 12: 501-508.
  46. Lee N, Wong CK, Chan PKS, Lun SW, Lui G, Wong B, Hui DS, Lam CW, Cockram CS, Choi KW, Yeung AC, Tang JW, Sung JJ. Hypercytokinemia and hyperactivation of phosphop38 mitogen-activated protein kinase in severe human influenza A virus infection. Clinical Infectious Diseases 2007; 45: 723-731.
  47. Chik KW, Li CK, Chan PKS, Shing MM, Lee V, Tam JS, Yuen PM. Oseltamivir prophylaxis during the influenza season in a paediatric cancer centre: prospective observational study. Hong Kong Medical Journal 2004; 10: 103-106.
  48. Chan PKS*. Outbreak of avian influenza A (H5N1) virus infection in Hong Kong in 1997. Clinical Infectious Diseases 2002; 34 (Suppl 2): S58-64.
  49. To KF, Chan PKS, Chan KF, Lee WK, Lam WY, Wong KF, Tang NL, Tsang DN, Sung RY, Buckley TA, Tam JS, Cheng AF. Pathology of fatal human infection associated with avian influenza A H5N1 virus. Journal of Medical Virology 2001; 63: 242-246.
  50. Bridges CB, Katz JM, Seto WH, Chan PKS, Tsang D, Ho W, Mak KH, Lim W, Tam JS, Clarke M, Williams SG, Mounts AW, Bresee JS, Conn LA, Rowe T, Hu-Primmer J, Abernathy RA, Lu X, Cox NJ, Fukuda K. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. Journal of Infectious Diseases 2000; 181: 344-348.
  51. Yuen KY, Chan PKS, Peiris M, Tsang DN, Que TL, Shortbridge KF, Cheung PT, To WK, Ho ET, Sung R, Cheng AF, and members of the H5N1 study group. Clinical features and rapid viral diagnosis of human disease associated with avian influenza H5N1 virus. Lancet 1998; 351: 467-471.